AcuiSee - Rodent Visual Acuity Using Behavioral Conditioning
Live date was Nov 17th, 2021
Missed the live date? Don't worry!
Scroll down to watch the event.
Description
In this presentation, Dr. Jeff Jamison will briefly describe the current methods typically used to measure vision in animals. He will then discuss the basic concepts of operant conditioning and how it can be used to train rodents to perform visual tasks and measure the threshold of vision or visual acuity. The AcuiSee Vision Chamber, which Dr. Jamison has developed, is such a dedicated operant chamber used to measure vision in rodents. He will touch upon the calibration studies done to demonstrate a range of visual functions, pharmacological intervention, and disease modeling. Finally, he will discuss additional applications of the AcuiSee system, together with its potential in basic science research, toxicological screening, and pharmacological testing.
Key Topics
- Measuring rodent vision
- Operant conditioning
- Rodent visual acuity measurement
- AcuiSee – automated vision testing system
Learning Objectives
- Operant conditioning and how it relates to determining vision in animals
- How visual acuity and contrast sensitivity are related
- Advantages of the AcuiSee system as a dedicated automated vision testing system
- How rodents can be trained to perform visual tasks to measure their visual threshold or acuity
- Applications of the AcuiSee system for basic research, toxicological screening and pharmacological testing
Background Reading
Light and Dark discrimination testing in Gnb3-/- rats. Marianna Bacellar-Galdino; John Rozofsky; Simon M Petersen-Jones; Jeffrey Adam Jamison
Invest. Ophthalmol. Vis. Sci. 2020;61(7):4280.
High-Throughput Visual Acuity Device for Rats: Training and Development. Jeffrey Jamison; Scott Baron; Thomas Vihtelic
Invest. Ophthalmol. Vis. Sci. 2013;54(15):3411
A behavioural operant discrimination model for assessment and pharmacological manipulation of visual function in rats. Mikael A Carlsson, M D Swedberg
Brain Res. 2010 Mar 19;1321:78-87.
doi: 10.1016/j.brainres.2010.01.029.
About the speaker
Dr. Jeffrey A Jamison
Director of Pharmacology
Experimentica Ltd.
Dr. Jamison is an experienced Drug Development and Vision Scientist, Serial Entrepreneur, and Consultant with over 25 years of ocular research expertise. He has formed several successful companies in the pharmaceutical and device development industry. In his role as President of Acuisee, Inc., Jeff has interests in systems to measure vision of animals to support welfare and drug discovery efforts. As Director of Pharmacology at Experimentica he leads a team of scientists to support ocular R&D efforts for companies from small start-ups to large pharma.
Watch the Presentation
Other Journal Clubs and Webinars
Journal Club: Monitoring Refractive Development in Mice to Investigate Mechanisms of Myopia
- Related Products:
- PhotoRefractor
Symposium: Opportunities, Hopes, and Challenges in Translating Visual Restoration from Mouse to Human
- Related Products:
- OptoDrum
Journal Club: Postsynaptic Neuronal Activity Promotes Retinal Axon Regeneration
- Related Products:
- OptoDrum
Journal Club: Inherited Retinal Dystrophy: Chronic Proinflammatory Signaling Accelerates the Rate of Degeneration
- Related Products:
- OptoDrum
Journal Club: Developing Retinal Gene Therapy for Zellweger Spectrum Disorder (ZSD)
- Related Products:
- OptoDrum
Journal Club: In Vivo Modeling of Immune-mediated Optic Neuropathies
- Related Products:
- OptoDrum
Journal Club: Endothelial Caspase-9 Mediates Inflammatory and Vision Function Changes in Retinal Vascular Injury
- Related Products:
- OptoDrum
- Applications:
Journal Club: Anti-FcRn Treatment in Antibody-Associated Experimental Autoimmune Encephalomyelitis
- Related Products:
- OptoDrum
Journal Club: IR Photorefraction and IR Photokeratometry – Measuring Refractive State and Corneal Curvature in Animals and Humans
- Applications:
- Myopia
Journal Club: Echolocation with Light – A New Form of Active Sensing in Fish?
- Related Products:
- OptoDrum
- Applications:
- Vision Science
Journal Club: Assessing Neuroinflammation-related Neural Damage by Monitoring the Retinotectal System
- Related Products:
- OptoDrum
Journal Club: Restoring vision – Optogenetic gene therapy targeted at human ON-bipolar cells
- Related Products:
- OptoDrum
Journal Club: The role of Nogo-A in visual deficits induced by retinal injury.
- Related Products:
- OptoDrum
Webinar: Visual Acuity as a Relevant Phenotype in Mouse Models of Rare Disease
- Related Products:
- OptoDrum