# Striatech: Your Experts for Neuroscience Testing Tools

> Learn more about the best in class animal visual behavior tracking with the OptoDrum by Striatech, Tübingen, Germany

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## Pages
- [Applications](https://stria.tech/applications/)
- [OptoDrum \(Copy\)](https://stria.tech/products/optodrum-2/): Striatech's OptoDrum automatically determines the visual abilities of mice and rats\. Based on the optomotor reflex, the OptoDrum's fully automated and reliable analysis finds visual acuity and contrast sensitivity quickly and objectively\.
- [OptoDrum](https://stria.tech/products/optodrum/): Striatech's OptoDrum automatically determines the visual abilities of mice and rats\. Based on the optomotor reflex, the OptoDrum's fully automated and reliable analysis finds visual acuity and contrast sensitivity quickly and objectively\.
- [home](https://stria.tech/)
- [Keratometer](https://stria.tech/products/keratometer/): Striatech's Keratometer allows to determine the radius of corneal curvature within seconds\.

## Posts
- [Journal Club: Seeing White Matter Aging Through the Visual System](https://stria.tech/latest-news/microglia-white-matter-aging/): This Journal Club by Janos Groh et al\. covers white matter aging and neuro\-immune interactions\. Aging is associated with progressive white matter degeneration\. Dysfunctional microglia drive the recruitment and retention of pathogenic CD8\+ T cells through chemokine\-mediated signaling, promoting neuroinflammation in aging white matter\. Glial–immune interactions contribute to structural and functional decline, with microglia–immune crosstalk as a key driver of age\-related neurodegeneration\.
- [ISER 2026: Let's Connect in Valencia](https://stria.tech/latest-news/iser-2026-lets-connect-in-valencia/): Meet Striatech at ISER in Valencia\! Discover how our solutions can support your studies and experiments\.
- [Advancing Myopia Research: Striatech Myopia Suite](https://stria.tech/latest-news/striatech-myopia-suite/): The Striatech Myopia Suite combines automated refractive state measurement and corneal curvature analysis into one seamless workflow\. Developed with Prof\. Frank Schaeffel, it enables precise, reliable data collection in small animal myopia research\.
- [Journal Club: Gene\-Agnostic Gene Therapy to Preserve Vision](https://stria.tech/events/journal-club/journal-club-gene-agnostic-gene-therapy-to-preserve-vision/): This Journal Club features innovative research by Harvard's Cepko lab, exploring gene\-independent strategies to preserve vision in retinitis pigmentosa and other genetic forms of blindness\. Using AAVs to enhance metabolic support, including MCT2 expression in retinal pigment epithelial cells, they preserved cone photoreceptors and maintained color and daylight vision across diverse genotypes\.
- [Journal Club: Photoreceptor Cell Therapy to Treat Advanced Retinal Degeneration](https://stria.tech/events/journal-club/photoreceptor-cell-therapy-advanced-retinal-degeneration/): This Journal Club highlights research by Rachael Pearson et al\. on photoreceptor transplantation\.
Photoreceptor transplantation has long been proposed as a strategy to restore vision, but in advanced retinal degeneration it remained unclear whether the inner retinal neurons could still accept and process new inputs from donor cells\. The study shows that human pluripotent stem cell–derived cone photoreceptors can integrate into end\-stage mouse retinas, drive retinal function, and induce behavioral responses, revealing that even severely degenerated retinas retain the capacity to remodel in response to healthy photoreceptors\.

## Background and Methods
- [Visual Environment and Refractive Development: Form Deprivation and Lens\-Induced Myopia](https://stria.tech/background-and-methods/visual-environment-refractive-development-form-deprivation-lens-induced-myopia/)
- [Visual Acuity in Rodents](https://stria.tech/background-and-methods/visual-acuity-in-rodents/)
- [Measuring Refractive State in Alert Laboratory Animals: A Photorefraction Protocol](https://stria.tech/background-and-methods/measuring-refractive-state-alert-laboratory-animals-photorefraction-protocol/)
- [Photorefractor vs Keratometer: Complementary Tools for Myopia Research](https://stria.tech/background-and-methods/photorefractor-vs-keratometer-complementary-tools-myopia-research/)
- [Choosing Animal Models for Optical and Myopia Research: Chicks, Guinea Pigs, Mice, and Rats](https://stria.tech/background-and-methods/choosing-animal-models-optical-myopia-research-chicks-guinea-pigs-mice-rats/)

## Publications
- [Intracellular complement factor H protects neurons during CNS inflammation](https://stria.tech/publications/intracellular-complement-factor-h-protects-neurons-during-cns-inflammation/): This study identifies a previously unknown self\-protection system in nerve cells that may help explain why some neurons survive inflammation better than others in multiple sclerosis \(MS\)\. The researchers found that neurons can increase production of complement factor H \(CFH\), a protein best known for its role in the immune system; inside neurons, it appears to reduce damaging oxidative stress and protect vulnerable cells from degeneration\. In mouse models of MS\-like disease, removing CFH from neurons worsened nerve\-cell loss and visual problems, whereas boosting protective CFH components helped preserve neurons\. Visual function in these mice was assessed using Striatech's OptoDrum, which was used to measure visual acuity and contrast sensitivity\. These findings point to CFH as a potential starting point for future treatments aimed at making neurons more resilient to chronic inflammation\.
- [Targeting AKT via SC79 for Photoreceptor Preservation in Retinitis Pigmentosa Mouse Models](https://stria.tech/publications/akt-activation-retinitis-pigmentosa-sc79/): Brunet et al tested SC79, and activator of the pro\-survival kinase AKT, as a neuroprotective strategy in retinitis pigmentosa mouse models\. Intravitreal SC79 \(10–100 µM\) was well tolerated in wildtype mice\. In rd1\.GFP mice, it partially preserved peripheral photoreceptor cell layer thickness, rod\-driven contrast sensitivity, and cone morphology\. In RhoP23H\.GFP mice, the effects of SC79 were minimal\. AKT pathway markers confirmed target engagement, but overall functional rescue remained modest, indicating that dosing and delivery require further optimization\.
- [Characterizing Visual Manifestations in NMOSD and MOGAD Mouse Models](https://stria.tech/publications/modeling-mog-antibody-associated-disorder-and-neuromyelitis-optica-spectrum-disorder-in-animal-models-visual-system-manifestations/): This study evaluated whether antibody\-driven mouse models of neuromyelitis optica spectrum disorder \(NMOSD\) and myelin oligodendrocyte glycoprotein antibody\-associated disease \(MOGAD\) reproduce the distinct visual outcomes observed in patients\. Researchers induced experimental autoimmune encephalomyelitis and administered disease\-specific antibodies before assessing visual acuity, retinal structure, and optic nerve pathology over time\. Both models developed similar visual impairment and retinal degeneration, despite subtle histological differences in optic nerve inflammation\. Visual acuity was measured using the OptoDrum to monitor disease progression\. 
- [New Genetic Links Between LILRB2 and Pathological Myopia](https://stria.tech/publications/genome-wide-association-analysis-identifies-lilrb2-gene-for-pathological-myopia/): In a genome\-wide association study in East Asian populations, Jiang et al investigated genetic risk factors for pathological myopia \(PM\), a leading cause of blindness\. They identified LILRB2 as a new candidate gene associated with PM\. LILRB2 upregulation promotes fatty acid synthesis and lipid accumulation, leading to choroidal dysfunction and PM development, both in human patients and in mouse models\. These findings provide insights into the molecular mechanisms of PM pathogenesis related to lipid metabolism disorders\.
Striatech's Photorefractor was used to measure refraction errors in mice, while the Keratometer was employed to measure corneal curvature\. These tools allowed for precise ocular measurements in the animal models, contributing to the understanding of PM's genetic and physiological aspects\.

- [When Brain Defenders Turn Destructive: How Microglia and T Cells Promote Age\-Related Decline](https://stria.tech/publications/microglia-activation-aging-related-white-matter-degeneration/): As we get older, immune cells in the brain called microglia can become overactive and attract aggressive CD8\+ T cells\. These T cells then attack the brain’s axons' protective layer, known as myelin, leading to its damage and a decline in brain function\. Groh et al reveal the chain reaction behind these age\-related brain changes and point to new opportunities for preventing or slowing down brain degeneration\. The OptoDrum assay confirmed the link between axon degeneration and behavioral vision deficits\.

## Categories
- [Latest News](https://stria.tech/latest-news/)
- [Events](https://stria.tech/events/)
- [Journal Club](https://stria.tech/events/journal-club/)
- [Past Meetings](https://stria.tech/conferences-and-meetings/past-meetings/)
- [Conferences and Meetings](https://stria.tech/conferences-and-meetings/)

## Applications
- [Retinal Degeneration](https://stria.tech/application/retinal-degeneration/)
- [Neuroinflammation](https://stria.tech/application/neuroinflammation/)
- [Blindness](https://stria.tech/application/blindness/)
- [Rare Disease](https://stria.tech/application/rare-disease/)
- [Myopia](https://stria.tech/application/myopia/)

## Optional
- [Sitemap index](https://stria.tech/sitemap_index.xml)