Journal Club: Developing a Novel Gene Therapy for Kcnv2 Retinopathy

STRIA TECHEvents, Journal Club, Latest News

This Journal Club demonstrates the effectiveness of an AAV-based gene therapy in rescuing vision and restoring normal retinal responses in a mouse model of KCNV2 retinopathy, a genetic form of irreversible blindness caused by mutations in the Kv8.2 subunit of voltage-gated potassium channels. Efficacy tests were carried out with Striatech’s OptoDrum and ScotopicKit, among others.

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Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

Muriel Haag

The chromatin in the nucleus of rod photoreceptors has an inverted structure in nocturnal animals. Metabolically, this is expensive to maintain, so it has been proposed that the inverted architecture provides an advantage during night vision. Subramanian et al could show with our OptoDrum that the inverted nuclear architecture provides improved contrast sensitivity in dark environments.

Journal Club: Measuring Visual Acuity and Contrast Sensitivity by Optomotor Reflex in Rodents

STRIA TECHEvents, Journal Club

In vision research, observing the optomotor reflex (OMR) is an important and widely established method for assessing visual acuity and contrast sensitivity in rodents. In this event, we will hear about several applications of OMR measuremnts, ranging from quantification of retinal degeneration to characterization of night vision.

Come and visit Striatech’s Virtual Booth 


Talk to our company founders online and learn about the benefits of optomotor reflex (OMR) measurements to monitor visual performance in lab rodents. Get to know our OptoDrum for automated OMR measurements and discuss your specific research application.

Interested? Book your 15 min time slot here:

Book a time slot

We are looking forward to meeting you online!


Striatech’s ScotopicKit lets you extend the applications of your OptoDrum. With filter foils, you can stepwise reduce absolute light levels inside the OptoDrum to near darkness. Whether you want to monitor rod-based diseases, or ask questions about light adaptation – with the ScotopicKit you can evaluate your animals’ visual threshold at different light levels, and characterize rod-driven vision.