This Journal Club demonstrates the effectiveness of an AAV-based gene therapy in rescuing vision and restoring normal retinal responses in a mouse model of KCNV2 retinopathy, a genetic form of irreversible blindness caused by mutations in the Kv8.2 subunit of voltage-gated potassium channels. Efficacy tests were carried out with Striatech’s OptoDrum and ScotopicKit, among others.
Find us at booth #2523 in Denver! After more than 3 years, we cannot wait to connect with you in-person again.
The chromatin in the nucleus of rod photoreceptors has an inverted structure in nocturnal animals. Metabolically, this is expensive to maintain, so it has been proposed that the inverted architecture provides an advantage during night vision. Subramanian et al could show with our OptoDrum that the inverted nuclear architecture provides improved contrast sensitivity in dark environments.
In vision research, observing the optomotor reflex (OMR) is an important and widely established method for assessing visual acuity and contrast sensitivity in rodents. In this event, we will hear about several applications of OMR measuremnts, ranging from quantification of retinal degeneration to characterization of night vision.
Talk to our company founders online and learn about the benefits of optomotor reflex (OMR) measurements to monitor visual performance in lab rodents. Get to know our OptoDrum for automated OMR measurements and discuss your specific research application.
Interested? Book your 15 min time slot here:
We are looking forward to meeting you online!
Dr. Subramanian published a paper showing how the chromatin architecture found in night-active animals provides a visual advantage under scotopic …
Striatech’s Scotopic Kit for scotopic testing with the OptoDrum is now available for purchase. Whether you want to monitor rod-based …
Striatech’s ScotopicKit lets you extend the applications of your OptoDrum. With filter foils, you can stepwise reduce absolute light levels inside the OptoDrum to near darkness. Whether you want to monitor rod-based diseases, or ask questions about light adaptation – with the ScotopicKit you can evaluate your animals’ visual threshold at different light levels, and characterize rod-driven vision.
In cooperation with InsightScientific and our North American sales partner Stoelting, Striatech is giving a webinar about measuring visual acuity and …
