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Abundant Neural circRNA Cdr1as Is Not Indispensable for Retina Maintenance

Frontiers in Cell and Developmental Biology (Nov 06, 2020)

Abundant Neural circRNA Cdr1as Is Not Indispensable for Retina Maintenance

Chen XJ, Li ML, Wang YH, Mou H, Wu Z, Bao S, Xu ZH, Zhang H, Wang XY, Zhang CJ, Xue X, Jin ZB.
The role of circular RNAs is not well understood, including Cdr1as, which is abundant in vertebrate retina. Chen et al show that CDR1as-KO mice had only minor deficits. Those included reduced contrast sensitivity, as measured with our OptoDrum. Overall, however, Cdr1as abundance is not required for retinal development and maintenance.
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