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Neuron (Jan 04, 2023)
CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism
Slavi N, Balasubramanian R, Lee MA, Liapin M, Oaks-Leaf R, Peregrin J, Potenski A, Troy CM, Ross ME, Herrera E, Kos-midis S, John SWM, Mason CA
DOI: 10.1016/j.neuron.2022.10.025 >>
This article is an in-depth investigation of molecular alterations underlying chiasmatic misrouting in the albino binocular circuit. During development, in a specialized retinal niche—the ciliary margin—fewer cells express the cellcycle regulator CyclinD2. Consequently, the cell cycle is elongated, resulting in fewer ipsilaterally projecting RGCs and perturbed binocular vision.
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