Journal Club: Visual Function with Aging in Normal and Alzheimer’s Disease Model Mice

STRIA TECHJournal Club, Latest News

This Journal Club highlights the conservation of rod, cone, and melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) between mice and humans, facilitating the translation of visual function studies to clinical settings. It examines early degeneration of ipRGCs in Alzheimer’s models and human post-mortem retinas, and discusses how non-invasive assessments of visual acuity, contrast sensitivity, and pupillary light reflex in both species may serve as early biomarkers for Alzheimer’s Disease. Visual acuity and contrast sensitivity measurements were conducted using Striatech’s OptoDrum.

Unveiling the Mysteries of Albinism: Disrupted Retinal Harmony Due to CyclinD2 Deficiency

STRIA TECHLatest News

Albino mice, with their characteristic white fur and red eyes due to melanin deficiency, experience impaired vision, particularly in retinal development, affecting neuron targeting from the retina to the brain. Slavi et al. identified CyclinD2 as crucial in this process, finding its downregulation disrupts the cell cycle and RGC balance. Increasing intracellular calcium levels to upregulate CyclinD2 restored proper cell cycle progression and depth perception in albino mice, suggesting potential therapies for albinism-related vision disorders.

New Sales Partner for North America

STRIA TECHLatest News

Striatech is excited to announce our partnership with Phoenix-Micron, Inc., making them our exclusive sales representative for the USA and Canada. This collaboration enhances accessibility to our expanding product portfolio, particularly benefiting the North American scientific community. We’re committed to supporting your scientific pursuits and welcome inquiries about our products and discussions on your research needs.

Journal Club: Developing a Novel Gene Therapy for Kcnv2 Retinopathy

STRIA TECHEvents, Journal Club, Latest News

This Journal Club demonstrates the effectiveness of an AAV-based gene therapy in rescuing vision and restoring normal retinal responses in a mouse model of KCNV2 retinopathy, a genetic form of irreversible blindness caused by mutations in the Kv8.2 subunit of voltage-gated potassium channels. Efficacy tests were carried out with Striatech’s OptoDrum and ScotopicKit, among others.