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This Journal Club highlights research by Rachael Pearson et al. on photoreceptor transplantation. Photoreceptor transplantation has long been proposed as a strategy to restore vision, but in advanced retinal degeneration it remained unclear whether the inner retinal neurons could still accept and process new inputs from donor cells. The study shows that human pluripotent stem cell–derived cone photoreceptors can integrate into end-stage mouse retinas, drive retinal function, and induce behavioral responses, revealing that even severely degenerated retinas retain the capacity to remodel in response to healthy photoreceptors.