Research Applications for Striatech Products
Nature Neuroscience (Jun 28, 2025)
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration
Groh J, Feng R, Yuan X, Liu L, Klein D, Hutahaean G, Butz E, Wang Z, Steinbrecher L, Neher J, Martini R, Simons M.
DOI: 10.1038/s41593-025-01955-w >>
As we get older, immune cells in the brain called microglia can become overactive and attract aggressive CD8+ T cells. These T cells then attack the brain’s axons’ protective layer, known as myelin, leading to its damage and a decline in brain function. Groh et al reveal the chain reaction behind these age-related brain changes and point to new opportunities for preventing or slowing down brain degeneration. The OptoDrum assay confirmed the link between axon degeneration and behavioral vision deficits.
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