OptoDrum
Striatech's OptoDrum automatically determines the visual abilities of mice and rats. Based on the optomotor reflex, the OptoDrum's fully automated and reliable analysis finds visual acuity and contrast sensitivity quickly and objectively.
For a wide range of pre-clinical research applications, the OptoDrum is a convenient, automated, fast, and objective in-vivo tool to screen for visual dysfunction and disease progression.
Ophthalmology
Measure visual abilities- Contrast sensitivity
- Visual acuity
- Track retinal degeneration
- Evaluate new treatment options (stem cells, optogenetics, neuroprotection, ...)
Pharmacology
Efficacy and safety testing- Efficacy: test novel ophthalmic drugs
- Safety: screen for side effects of new compounds
Disease Models
Track disease progression- Retinal degeneration
- Glaucoma
- Axon degeneration
- Axon regeneration
- Multiple Sclerosis
- Neuroinflammation
- Stroke
- Diabetes
- Aging
Toxicology
Vision defect screening- Testing effects of environmental stress
- Testing effects of neurotoxic substances
Phenotyping
New genetic lines- Characterize vision of new lines
- Screen for visual dysfunctions
Fully automated process
Automated animal detection · Automated optomotor reflex analysis · Automated adjustement of stimulus pattern · Automated assessment of visual threshold · Fast, objective, and bias-free results
Non-invasive
No fixation or surgery is required · Animal can freely move inside the arena · Disease progression can be monitored over time because animals can be tested repeatedly, even daily
Cost saving and effective
No animal training is necessary · No training of personnel needed: the software does the work for you! · Takes as little as 4 min per animal
Easy handling and maintenance
For mice and rats
Larger OptoDrumPLUS available for experiments with rats · OptoDrumPLUS can also be used with mice
Test rod-specific vision
Scotopic kit available to test rod vision · Variable adjustment of brightness in steps of 1 log unit
OptoDrum (for mice)
OptoDrumPLUS (for mice and rats)
Dimensions
54x54x30 cm
55x55x72 cm
70x70x75 cm
75x75x98 cm
ca. 62 kg
ca. 79 kg
Display Panels
Monitors
23.8" 16:9 full-HD IPS panels
27.6" 16:18 SDQHD Nano-IPS panels
Viewing Angle
178° vertical and horizontal
178° vertical and horizontal
Color Mode
DICOM
sRGB
Brightness
250 cd/m²
300 cd/m²
Arena
Mirrors
Top and bottom mirrors
Top mirror
Animal Platform
Elevated platform in different colors
Elevated platform in different colors
Access
Front door: easy animal handling and cleaning
Front door: easy animal handling and cleaning
Computer
Computer
State-of-the-art workstation
Video Card
High-quality video card for multi-monitoring
Camera
Type
Compact industrial camera
Compact industrial camera
Sensor
IR-sensitive 1/3" CMOS sensor with global shutter
IR-sensitive 1/3" CMOS sensor with global shutter
Lens
Wide angle lens, F1.6
Wide angle lens, F1.6
Software
Data
Open file format: All data fully accessible
Open file format: All data fully accessible
Automation
Everything is automated - manual intervention possible at every step
Everything is automated - manual intervention possible at every step
Analysis
Left and right eye can be analyzed independently
Left and right eye can be analyzed independently
This will contain the slide number
Standard OptoDrum.
Four computer monitors surround the animal arena. The standard version of the OptoDrum is ideally suited for experiments with mice. It is a complete system, including camera, computer, and software, that can be used right out of the box.
OptoDrumPLUS
Can be used with both mice and rats. Both OptoDrum versions have a front door, which makes animal handling very convenient, and which allows easy cleaning of the arena.
For a wide range of pre-clinical research applications, the OptoDrum is a convenient, automated, fast, and objective in-vivo tool to screen for visual dysfunction and disease progression.
Ophthalmology
Measure visual abilities- Contrast sensitivity
- Visual acuity
- Track retinal degeneration
- Evaluate new treatment options (stem cells, optogenetics, neuroprotection, ...)
Pharmacology
Efficacy and safety testing- Efficacy: test novel ophthalmic drugs
- Safety: screen for side effects of new compounds
Disease Models
Track disease progression- Retinal degeneration
- Glaucoma
- Axon degeneration
- Axon regeneration
- Multiple Sclerosis
- Neuroinflammation
- Stroke
- Diabetes
- Aging
Toxicology
Vision defect screening- Testing effects of environmental stress
- Testing effects of neurotoxic substances
Phenotyping
New genetic lines- Characterize vision of new lines
- Screen for visual dysfunctions
Fully automated process
Automated animal detection · Automated optomotor reflex analysis · Automated adjustement of stimulus pattern · Automated assessment of visual threshold · Fast, objective, and bias-free results
Non-invasive
No fixation or surgery is required · Animal can freely move inside the arena · Disease progression can be monitored over time because animals can be tested repeatedly, even daily
Cost saving and effective
No animal training is necessary · No training of personnel needed: the software does the work for you! · Takes as little as 4 min per animal
Easy handling and maintenance
For mice and rats
Larger OptoDrumPLUS available for experiments with rats · OptoDrumPLUS can also be used with mice
Test rod-specific vision
Scotopic kit available to test rod vision · Variable adjustment of brightness in steps of 1 log unit
OptoDrum (for mice)
OptoDrumPLUS (for mice and rats)
Dimensions
54x54x30 cm
55x55x72 cm
70x70x75 cm
75x75x98 cm
ca. 62 kg
ca. 79 kg
Display Panels
Monitors
23.8" 16:9 full-HD IPS panels
27.6" 16:18 SDQHD Nano-IPS panels
Viewing Angle
178° vertical and horizontal
178° vertical and horizontal
Color Mode
DICOM
sRGB
Brightness
250 cd/m²
300 cd/m²
Arena
Mirrors
Top and bottom mirrors
Top mirror
Animal Platform
Elevated platform in different colors
Elevated platform in different colors
Access
Front door: easy animal handling and cleaning
Front door: easy animal handling and cleaning
Computer
Computer
State-of-the-art workstation
Video Card
High-quality video card for multi-monitoring
Camera
Type
Compact industrial camera
Compact industrial camera
Sensor
IR-sensitive 1/3" CMOS sensor with global shutter
IR-sensitive 1/3" CMOS sensor with global shutter
Lens
Wide angle lens, F1.6
Wide angle lens, F1.6
Software
Data
Open file format: All data fully accessible
Open file format: All data fully accessible
Automation
Everything is automated - manual intervention possible at every step
Everything is automated - manual intervention possible at every step
Analysis
Left and right eye can be analyzed independently
Left and right eye can be analyzed independently
This will contain the slide number
Standard OptoDrum.
Four computer monitors surround the animal arena. The standard version of the OptoDrum is ideally suited for experiments with mice. It is a complete system, including camera, computer, and software, that can be used right out of the box.
OptoDrumPLUS
Can be used with both mice and rats. Both OptoDrum versions have a front door, which makes animal handling very convenient, and which allows easy cleaning of the arena.
Customer voices
I cannot tell you how happy I am to have the OptoDrum. The fact that it is easy to use and it relies on an unbiased method to determine ‘yes’ or ‘no’ decisions for mouse behavior helps a lot in designing and conducting experiments.Dr. Abdoulaye Sene, Genentech
The results are finally objective. Until now, it was difficult or even impossible to compare data collected by different users.Prof. Volker Enzmann, University Bern, Switzerland
The OptoDrum has a user friendly and sturdy design. It is incredibly easy to use and delivers results right away. On top of this, Striatech provides great support!Prof. Marius Ader, TU Dresden
Background: Measuring rodent vision with innate reflex-behavior
All animals have reflexes that help to stabilize the image of the moving environment in their eyes. For example, if a person looks out the window of a moving train her eyes automatically follow the landscape. These compensatory eye movements are caused by the so-called optokinetic reflex. Many animals also have the optomotor reflex which triggers compensatory head movements.
These compensatory eye and head movements are only triggered if the moving stimulus can be seen by the animal. Thus, observing these innate reflexes can be used as a quantitative readout for visual performance needs of animals. In mice and rats, observing the optomotor reflex is particulary convenient: it does not require fixation or surgery, because the corresponding behavior can be observed macroscopically.
OptoDrum: Functioning and Software
In the OptoDrum, the animal sits on an elevated platform, surrounded by computer monitors. A camera observes the behavior of the animal from above. We trigger the optomotor reflex with a black-and-white stripe pattern on the screens that rotates around the animal. By making the stripe pattern more difficult, one eventually reaches the threshold of the animal's vision and the reflex is not triggered anymore. This allows to determine the animal's visual acuity (by making the stripes finer) or contrast sensitivity (by reducing the contrast of the stripes).
This process is fully automated in the OptoDrum. The OptoDrum’s software easily guides you through the measurements. You can keep full control over the testing protocol, or you can let the OptoDrum determine your animal's visual threshold completely automatically.
The following picture gallery illustrates important concepts:
This will contain the slide number
Overview of OptoDrum function
The projected stripe pattern on the screens has the appearance of a round drum. It is continuously and automatically adjusted so that the animal is in the drum's center, to keep the angular width of the stripes constant.
A mouse inside the OptoDrum
The software gives you an immediate overview of the animal's behavior and the results of the experiment. While everything can be automated, you can have control of all aspects of the experiment if you wish.
OptoDrum publications
The role of inflammation in hereditary spastic paraplegia type 11
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Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma
Increasing the number and intensity of shock tube generated blast waves leads to earlier retinal ganglion cell dysfunction and regional cell death
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Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases
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Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma
Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome
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Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury
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Assessment of Visual Function and Retinal Histology in a Snf2h Knockout Mouse Model
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- Chromatin Remodelling>
Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects
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Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis
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Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
Modeling MOG Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Visual System Manifestations
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Erythropoietin Protects against Retinal Damage in A Rat Model of Optic Neuropathy via Glial Suppression
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The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage
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Vitamin C protects retinal ganglion cells via SPP1 in glaucoma and after optic nerve damage
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Alleviating early demyelination in ischaemia/reperfusion by inhibiting sphingosine-1-phosphate receptor 2 could protect visual function from impairment
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A visual opsin from jellyfish enables precise temporal control of G protein signalling
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Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice
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- Applications:
- Axon Degeneration>
Off Starburst Amacrine Cells in the Retina Trigger Looming-Evoked Fear Responses in Mice
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- Applications:
- Looming-Evoked Fear Responses>
CRISPR-mediated optogene expression from a cell-specific endogenous promoter in retinal ON-bipolar cells to restore vision
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Postsynaptic neuronal activity promotes regeneration of retinal axons
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MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice
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CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism
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- Applications:
- Albino Visual System>
Neurovascular injury associated non-apoptotic endothelial caspase-9 and astroglial caspase-9 mediate inflammation and contrast sensitivity decline
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Bipolar cell targeted optogenetic gene therapy restores parallel retinal signaling and high-level vision in the degenerated retina
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- Applications:
- Retinal Degeneration>
Validation of Mct8/Oatp1c1 dKO mice as a model organism for the Allan-Herndon-Dudley Syndrome
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Targeting Cholesterol Homeostasis Improves Recovery in Experimental Optic Neuritis
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Immune responses in mice after blast-mediated traumatic brain injury TBI autonomously contribute to retinal ganglion cell dysfunction and death
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- Applications:
- Traumatic Brain Injury (TBI)>
Identification of Nitric Oxide-Donating Ripasudil Derivatives with Intraocular Pressure Lowering and Retinal Ganglion Cell Protection Activities
In situ-crosslinked hydrogel-induced experimental glaucoma model with persistent ocular hypertension and neurodegeneration
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Noninvasive Ophthalmic Imaging Measures Retinal Degeneration and Vision Deficits in Ndufs4−/− Mouse Model of Mitochondrial Complex I Deficiency
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Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome
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Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in the rd10 Mouse Model
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TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis
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- Applications:
- Retinal Ischemia-Reperfusion Injury>
Chronic Proinflammatory Signaling Accelerates the Rate of Degeneration in a Spontaneous Polygenic Model of Inherited Retinal Dystrophy
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- Applications:
- Retinal Degeneration>
B cell-dependent EAE induces visual deficits in the mouse with similarities to human autoimmune demyelinating diseases
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- Applications:
- Autoimmune Demyelinating Diseases>
Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models
Antineonatal Fc Receptor Antibody Treatment Ameliorates MOG-IgG-Associated Experimental Autoimmune En-cephalomyelitis
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Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis
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- Applications:
- Multiple Sclerosis>
Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset
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- Neuroinflammation>
Abundant Neural circRNA Cdr1as Is Not Indispensable for Retina Maintenance
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Tau modulates visual plasticity in adult and old mice
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Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
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Molecular basis of impaired extraocular muscle function in a mouse model of congenital myopathy due to compound heterozygous Ryr1 mutations
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- Applications:
- Congenital Myopathy>
Empowering Retinal Gene Therapy with a Specific Promoter for Human Rod and Cone ON-Bipolar Cells
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Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injury
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Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
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The contrast sensitivity function of a small cryptobenthic marine fish
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Effects of the jimpy mutation on mouse retinal structure and function
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Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation
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Characterizing visual performance in mice: an objective and automated system based on the optokinetic reflex
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Accessories
ScotopicKit
Extend the applications of your OptoDrum to investigate light- or dark-adaptation and the functional contribution of rod photoreceptors to vision.
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DarkAdapt
Dark-adapt your animals in preparation for scotopic experiments. DarkAdapt can also be used to transport animals between your dark adaptation room and experimental room.
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Animal Platforms
Additional animal platforms for the OptoDrum.
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