It is difficult to measure small eyes of animal models. In this Journal Club, Prof. Frank Schaeffel presents his inventions for IR photorefraction and IR photokeratometry that facilitate such measurements. He focuses on the history, application, advantages, optics, software algorithms and calibration.
In this recent paper, Françoise Morin et al. show with our OptoDrum that a lack of histamine, unexpectedly, has no impact on the development and severity of Experimental Autoimmune Encephalomyelitis (EAE).
The “Standardization of Uveitis Nomenclature (SUN) Working Group” published classification criteria to help with better disease-specific approaches to diagnosis and treatment. For animal models of Uveitis, our OptoDrum provides a convenient readout tool to characterize diesease progression.
In this video of our series “OptoDrum Applications” Prof. Volker Enzmann from the University of Bern presents the results of his research on induced EAE, a model for optic neuropathy and multiple sclerosis.
Some fish use active photolocation: Their eyes emit light to detect predators or pray in this spotlight. In this Journal Club, Prof. Nico Michiels from the University of Tübingen will talk about his fascinating journey in which he has discovered this phenomenon.
In this video, Prof Volker Enzmann highlights an important topic: the relationship between retinal damage and optomotor behavior output is not necessarily linear, and it needs to be established for individual disease models. In the case of laser-induced local retinal damage, the optomotor behavior is only weakly affected, reflecting the surprising robustness of this reflex.
Summer Special: Schedule a free 14-day trial period and have the OptoDrum visit your lab!
Neuroinflammation amplifies neural damage caused by genetic disorders or aging. Groh et al show that neuroinflammation has deleterious consequences for the optic nerve, and disease progression can be monitored with the OptoDrum.
At this year’s ARVO, one of our OptoDrum users – Ms Anna Potenski from Columbia University – is presenting a poster on the topic of “Elucidating endothelial caspase-9 signaling pathways in retinal vein occlusion” containing OptoDrum data.
In this video of our series “OptoDrum Applications” Prof. Volker Enzmann from the University of Bern presents research with the Sodium Iodate Model (NaIO3) of Retinal Degeneration in mice.