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Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset

Brain Communications (Mar 03, 2021)

Immune modulation attenuates infantile neuronal ceroid lipofuscinosis in mice before and after disease onset

Groh J, Berve K, Martini R
Journal Club
CLN disease, a subtype of Batten disease, is characterized by progressive neurodegeneration with onset in early childhood. This also affects vision. Some immunomodulatory drugs are clinically established to significantly attenuate the condition. Groh et al show in a mouse model of CLN1 that such treatment can help both when given before symptom onset, and to a lesser degree also during disease progression, by interfering with neuroinflammatory activity of immune cells.
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