Striatech News

Experimental autoimmune encephalomyelitis (EAE) is the most widely used animal model for multiple sclerosis (MS), an autoimmune disease where the immune system attacks myelin, which coats neurons in the CNS. Histamine has been thought to play a role in MS, effecting disease progression either positively or negatively, depending on the location of histamine action. In this study, Morin et al created a conditional mouse KO model of Hdc, the enzyme that synthesizes histamine, and induced EAE in these mice. Surprisingly, while some phenotypes in these mice were consistent with the lack of histamine, it had no impact on the development and severity of EAE. One behavioral readout of the disease progression in EAE is the decline of visual acuity, which can be measured with our OptoDrum. Consistent with the other observation, visual acuity declined in EAE Hdc-KO animals in the same way as in EAE Hdc-WT animals.

In this video of our series “OptoDrum Applications” Prof. Volker Enzmann from the University of Bern presents the results of his research on induced EAE, a model for optic neuropathy and multiple sclerosis. 

In this video, Prof Volker Enzmann highlights an important topic: the relationship between retinal damage and optomotor behavior output is not necessarily linear, and it needs to be established for individual disease models. In the case of laser-induced local retinal damage, the optomotor behavior is only weakly affected, reflecting the surprising robustness of this reflex.

Summer Special: Schedule a free 14-day trial period and have the OptoDrum visit your lab!

At this year’s ARVO, one of our OptoDrum users – Ms Anna Potenski from Columbia University – is presenting a poster on the topic of “Elucidating endothelial caspase-9 signaling pathways in retinal vein occlusion” containing OptoDrum data.

In this video of our series “OptoDrum Applications” Prof. Volker Enzmann from the University of Bern presents research with the Sodium Iodate Model (NaIO3) of Retinal Degeneration in mice.

The lot has now fallen: We have a winner for our Advent calendar raffle from December 2020 where you could win one of our DarkAdapt boxes.

Watch the interview with our new collaboration partner Dr. Jeff Jamison, Director of In Vivo Pharmacology at Experimentica Ltd, and developer of AcuiSee.

Watch Striatech’s Expert to Expert Interview with Prof. Botond Roska from the Institute of Molecular and Clinical Ophthalmology Basel (IOB).

You couldn‘t attend our Journal Club on Oct 8th? Watch it now on demand!Register below to watch the presentation by

Just about to start a company or playing with the idea? Then watch the interview below with our own company

Striatech is hosting an online Journal Club Series where OptoDrum users present their data on various research topics. On October