Striatech News

T.J. Hollingsworth presents his work where he characterized a new polygenic mouse model of inherited retinal dystrophies, the BXD32 mouse strain. He presents evidence that a proinflammatory environment in the retina supports and accelerates the degeneration of the retina and the loss of visual function.

Peroxisomal disorders and the PEX1-G844D mouse model for mild Zellweger Spectrum Disorder (ZSD), leads to retinal degeneration and vision loss. Catherine Argyriou will describe how her team used AAV8-mediated gene delivery to robustly and durably improve functional vision, retinal response, retinal structure, and biochemical metabolites in ZSD-mice.

This presentation will outline the pathobiology and visual phenotype of immune mediated optic neuropathies that include Multiple Sclerosis (MS), Neuromylitis optica spectrum disorders (NMOSD), and Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Meet us at the 18th International Myopia Conference (IMC) in Rotterdam and see our Photorefractor and Keratometer!

In retinal vein occlusion (RVO), non-apoptotic expression of endothelial caspase-9 (EC Casp9) induces pathology including retinal edema, capillary ischemia, and neurodegeneration. Crystal Colón Ortiz presents mechanistic insights into EC Casp9 action, and the behavioral consequences such as contrast sensitivity decline.

Find us at booth #2523 in Denver! After more than 3 years, we cannot wait to connect with you in-person again.

Jana Remlinger et al. showed preserved visual function and ameliorated course of disease after anti-FcRn treatment in an experimental model using a monoclonal MOG-IgG to mimic MOGAD.

In this “OptoDrum Applications” video, Dr. Maximiliano Presa from The Jackson Laboratory presents results of his research in a model of Multiple Sulfatase Deficiency (MSD).

Scientists from Harvard Medical School were able to reverse the consequences of aging in the visual system, successfully treating optic nerve injury and glaucoma. Here is an overview of their 2020 study and it´s key findings.

Neuroinflammation can have devastating degenerative consequences in the central nervous system when the immune system attacks the body’s own cells. This paper shows that neuroinflammation can be attenuated by treatment with proper pharmacological substances. This has beneficial consequences from the cellular to the behavioral level. For example, Berve et al show with our OptoDrum that vision degenerates strongly in Ppt1-/- mice due to optic nerve atrophy. Pharmacological inhibition of innate immune cells ameliorates those effects.

Next week, on October 14th, it is world sight day, themed “#LoveYourEyes”, and the whole of October is blindness awareness month. Both events are meant to guide global attention to vision impairment and blindness, strengthen vision research, and improve access to eyecare worldwide.

Striatech offers new products for research on Myopia, a chronic progressive eye disease. It is estimated that by 2050, almost 50% of the world population will be myopic. But Myopia also leads to numerous secondary eye diseases that can even lead to blindness.