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Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

Journal of Neuroinflammation (Oct 28, 2020)

Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

Berve K, West BL, Martini R, Groh J
Neuroinflammation can have devastating degenerative consequences in the central nervous system when the immune system attacks the body’s own cells. This paper shows that neuroinflammation can be attenuated by treatment with proper pharmacological substances. This has beneficial consequences from the cellular to the behavioral level. For example, Berve et al show with our OptoDrum that vision degenerates strongly in Ppt1-/- mice due to optic nerve atrophy. Pharmacological inhibition of innate immune cells ameliorates those effects.
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