Albino mice, with their characteristic white fur and red eyes due to melanin deficiency, experience impaired vision, particularly in retinal development, affecting neuron targeting from the retina to the brain. Slavi et al. identified CyclinD2 as crucial in this process, finding its downregulation disrupts the cell cycle and RGC balance. Increasing intracellular calcium levels to upregulate CyclinD2 restored proper cell cycle progression and depth perception in albino mice, suggesting potential therapies for albinism-related vision disorders.
Neuroprotective Properties of Vitamin C Show Supporting Effects in Treating Glaucoma Patients
In their recent paper, Song Li and Tatjana C. Jakobs (Harvard Schepens Eye Research Institute) show how they have identified Vitamin C as a potential neuroprotective substance that could be used clinically in patients suffering from glaucoma. Striatech’s OptoDrum was used as readout tool for visual performance.
OptoDrum paper: Role of histamine in EAE
In this recent paper, Françoise Morin et al. show with our OptoDrum that a lack of histamine, unexpectedly, has no impact on the development and severity of Experimental Autoimmune Encephalomyelitis (EAE).
Uveitis – chances for new treatments
The “Standardization of Uveitis Nomenclature (SUN) Working Group” published classification criteria to help with better disease-specific approaches to diagnosis and treatment. For animal models of Uveitis, our OptoDrum provides a convenient readout tool to characterize diesease progression.
OptoDrum Applications – Induced Experimental Autoimmune Encephalomyelitis (EAE)
In this video of our series “OptoDrum Applications” Prof. Volker Enzmann from the University of Bern presents the results of his research on induced EAE, a model for optic neuropathy and multiple sclerosis.
Journal Club: Echolocation with Light – A New Form of Active Sensing in Fish?
Some fish use active photolocation: Their eyes emit light to detect predators or pray in this spotlight. In this Journal Club, Prof. Nico Michiels from the University of Tübingen will talk about his fascinating journey in which he has discovered this phenomenon.
OptoDrum Applications: Limitations of Optomotor Measurements for Laser-induced Damage
In this video, Prof Volker Enzmann highlights an important topic: the relationship between retinal damage and optomotor behavior output is not necessarily linear, and it needs to be established for individual disease models. In the case of laser-induced local retinal damage, the optomotor behavior is only weakly affected, reflecting the surprising robustness of this reflex.
Summer Special: OptoDrum free 14-day trial period
Summer Special: Schedule a free 14-day trial period and have the OptoDrum visit your lab!
Journal Club: Assessing Neuroinflammation-related Neural Damage by Monitoring the Retinotectal System
Neuroinflammation amplifies neural damage caused by genetic disorders or aging. Groh et al show that neuroinflammation has deleterious consequences for the optic nerve, and disease progression can be monitored with the OptoDrum.
ARVO 2021: Poster with OptoDrum Data by Columbia University
At this year’s ARVO, one of our OptoDrum users – Ms Anna Potenski from Columbia University – is presenting a poster on the topic of “Elucidating endothelial caspase-9 signaling pathways in retinal vein occlusion” containing OptoDrum data.
- Page 1 of 2
- 1
- 2