Unveiling the Mysteries of Albinism: Disrupted Retinal Harmony Due to CyclinD2 Deficiency

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Albino mice, with their characteristic white fur and red eyes due to melanin deficiency, experience impaired vision, particularly in retinal development, affecting neuron targeting from the retina to the brain. Slavi et al. identified CyclinD2 as crucial in this process, finding its downregulation disrupts the cell cycle and RGC balance. Increasing intracellular calcium levels to upregulate CyclinD2 restored proper cell cycle progression and depth perception in albino mice, suggesting potential therapies for albinism-related vision disorders.

OptoDrum Applications: Limitations of Optomotor Measurements for Laser-induced Damage

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In this video, Prof Volker Enzmann highlights an important topic: the relationship between retinal damage and optomotor behavior output is not necessarily linear, and it needs to be established for individual disease models. In the case of laser-induced local retinal damage, the optomotor behavior is only weakly affected, reflecting the surprising robustness of this reflex.