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StriatechJournal Club

Monitoring Refractive Development in Mice to Investigate Mechanisms of Myopia

Reece Mazade, Ph.D. - Emory University School of Medicine, Pardue Lab
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Live date was Oct 19th, 2023

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Description

Refractive development is a complicated process that involves matching the eye’s size with its optical power. A failure of this process leads to refractive error and blurred vision. The prevalence of myopia, the most common refractive error, is rapidly increasing worldwide, creating a wide public health concern. Currently, there is extensive effort to understand the mechanisms that underlie myopia development for better prevention. Monitoring refractive error in animal models using an automated Photorefractor has enabled in-depth investigations into these mechanisms and proved invaluable to achieving this goal.
In his presentation, Reece will show present data from several recent studies that use automated Photorefractor to investigate how different environmental, pharmacological, and genetic manipulations in mouse models affect refractive development and myopia progression.

Key Topics

  • Refractive error measurements are practical and reliable for monitoring refractive development and myopia in mice
  • Monitoring refractive error in animal models enables mechanistic investigations into myopia development

Learning Objectives

This talk will demonstrate the usefulness and feasibility of refractive error measurements in mice and discuss mechanisms of refractive development enabled by measurements using the automated Photorefractor.

Background Reading

Exogenous All-Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice. Brown DM, Yu J, Kumar P, Paulus QM, Kowalski MA, Patel JM, Kane MA, Ethier CR, Pardue MT.
Invest Ophthalmol Vis Sci. 2023 May 1;64(5):22.
doi: 10.1167/iovs.64.5.22.

Melanopsin Modulates Refractive Development and Myopia. Chakraborty R, Landis EG, Mazade R, Yang V, Strickland R, Hattar S, Stone RA, Iuvone PM, Pardue MT.
Exp Eye Res. 2022 Jan;214:108866.
doi: 10.1016/j.exer.2021.108866.

Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia. Brown DM, Kowalski MA, Paulus QM, Yu J, Kumar P, Kane MA, Patel JM, Ethier CR, Pardue MT.
Invest Ophthalmol Vis Sci. 2022 Dec 1;63(13):13.
doi: 10.1167/iovs.63.13.13.

Ambient Light Regulates Retinal Dopamine Signaling and Myopia Susceptibility. Landis EG, Park HN, Chrenek M, He L, Sidhu C, Chakraborty R, Strickland R, Iuvone PM, Pardue MT.
Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):28.
doi: 10.1167/iovs.62.1.28.

Short-Wavelength (Violet) Light Protects Mice From Myopia Through Cone Signaling. Strickland R, Landis EG, Pardue MT.
Invest Ophthalmol Vis Sci. 2020 Feb 7; 61(2):13.
doi: 10.1167/iovs.61.2.13

About the speaker

Reece Mazade, Ph.D.

Reece Mazade, Ph.D.

Research Scientist
Emory University School of Medicine, Pardue Lab

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Reece Mazade is a Research Scientist in the Pardue Laboratory investigating which retinal signaling pathways are affected in myopia. Dr. Mazade received his doctorate in Physiological Sciences and Neuroscience at the University of Arizona, studying retinal circuity. Prior to joining Emory, he completed post-doctoral training on an NIH NRSA Fellowship studying signaling pathways in visual cortex at SUNY College of Optometry. In addition to myopia, Dr. Mazade is also interested in understanding the signaling mechanisms that underlie visual processing.

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Journal Club: Monitoring Refractive Development in Mice to Investigate Mechanisms of Myopia
Oct 19th, 2023

    Striatech Journal Club - Emory University School of Medicine, Pardue Lab

    I already use refractive measurementsI want to do refractive measurements in the future

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