The role of circular RNAs is not well understood, including Cdr1as, which is abundant in vertebrate retina. Chen et al show that CDR1as-KO mice had only minor deficits. Those included reduced contrast sensitivity, as measured with our OptoDrum. Overall, however, Cdr1as abundance is not required for retinal development and maintenance.
Optogenetic gene therapy holds great promise for healing blindness. Hulliger et al have developed a new promoter that effectively targets human ON bipolar cells. This is an important step towards clinical applications of optogenetic gene therapy for restoring vision.
Nogo-A, an inhibitor of neural growth, prevents regeneration after injury. Blocking of Nogo-A aides recovery, also in the visual system after retinal damage. Baya Mdzomba show with our OptoDrum that visual behavior benefits from Nogo-A neutralization after retinal damage typically found in diabetic retinopathy or glaucoma.
Watch the interview with our new collaboration partner Dr. Jeff Jamison, Director of In Vivo Pharmacology at Experimentica Ltd, and developer of AcuiSee.
In this recent paper, Berve et al show with our OptoDrum the harm of neuroinflammation on the visual system, and the benefits of proper treatments.
The Jackson Laboratory will introduce their Neurobehavior Phenotyping Core, in which they also do visual acuity measurements. They will present two examples where the OptoDrum has been used to characterizte vision in animal models for rare disease: The Charcot-Marie-Tooth-disease, and Multiple-Sulfatase-Deficiency.
Watch Striatech’s Expert to Expert Interview with Prof. Botond Roska from the Institute of Molecular and Clinical Ophthalmology Basel (IOB).
You couldn‘t attend our Journal Club on Oct 8th? Watch it now on demand!Register below to watch the presentation by …
Talk to our company founders online and learn about the benefits of optomotor reflex (OMR) measurements to monitor visual performance in lab rodents. Get to know our OptoDrum for automated OMR measurements and discuss your specific research application.
Interested? Book your 15 min time slot here:
We are looking forward to meeting you online!
Dr. Subramanian published a paper showing how the chromatin architecture found in night-active animals provides a visual advantage under scotopic …
